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Misoprostol for Post-Abortion Care (PAC)

Post-abortion care (PAC) is a comprehensive approach to reducing deaths and injuries from incomplete and unsafe abortions and their related complications. PSI distributes misoprostol as an essential component of PAC. Misoprostol is a prostaglandin drug that stimulates cervical softening and uterine contractions, leading to uterine evacuation. It is inexpensive, stable at room temperature and is in tablet form, making it well suited to use in low income settings and at lower levels of healthcare systems.

Unit of interventionper tablet

Number of tablets per dosethree (if taken orally) or two (if taken sublingually)

Formulation200 mcg of prostaglandin per tablet

For more information about how PSI is increasing access to misoprostol to improve health and save lives, visit our website at:
http://www.psi.org/program/misoprostol-for-post-abortion-care/

Model Overview

PSI’s misoprostol for PPH impact model is based on the Lives Saved Tool (LiST). LiST is used to estimate the number of deaths averted with complete coverage of misoprostol in select countries, representing the projected impact of misoprostol. This number of deaths averted at the population level is translated to deaths averted per misoprostol tablet, using parameters such as the number of tablets required for each post-abortion treatment, number of live births, the abortion incidence ratio. Once we have deaths averted per misoprostol tablet, we apply data from the 2010 Global Burden of Disease study to estimate the corresponding number of DALYs averted.

Model Outputs (impact metrics)

Estimates of DALYs averted, deaths averted, CYPs provided, and unintended pregnancies averted represent the projected health impact of the intervention. It is projected because it has not been directly measured.

Examples based distribution of misoprostol tablets in Myanmar in 2015